binding

LOCUSLINK GENE SYMBOL GENENAME 2T3_low 2T3_C0 ML_low ML_hi LOCUSLINK CLASSIFICATIONS
11477 Acvr1 activin A receptor, type 1 1 5.185519028 11.84627274 14.15826053 ATP binding; integral to membrane; kinase activity; membrane; protein amino acid phosphorylation; protein kinase activity; protein serine/threonine kinase activity; receptor activity; receptor signaling protein serine/threonine kinase activity; transferase activity; transforming growth factor beta receptor activity; transmembrane receptor protein serine/threonine kinase activity; transmembrane receptor protein serine/threonine kinase signaling pathway
11568 Aebp1 AE binding protein 1 1 1.675541098 11.45541178 8.418967771 DNA binding; carboxypeptidase A activity; carboxypeptidase activity; cell adhesion; extracellular space; nucleus; proteolysis and peptidolysis; regulation of transcription, DNA-dependent; transcription corepressor activity
11752 Anxa8 annexin A8 1 2.085820753 5.427890543 2.2574445 blood coagulation; calcium ion binding; calcium-dependent phospholipid binding
12224 Klf5 Kruppel-like factor 5 1 0.704088798 3.03530993 1.743863521 DNA binding; nucleus; regulation of transcription, DNA-dependent
12332 Capg capping protein (actin filament), gelsolin-like 1 0.887852807 2.812627228 1.99749816 actin binding; nucleus
12336 Capn4 calpain, small subunit 1 1 1.521527835 1.593859188 0.964815684 calcium ion binding; calpain activity
12444 Ccnd2 cyclin D2 1 0.657749343 4.100971224 3.745424794 cell cycle; cyclin-dependent protein kinase regulator activity; cytokinesis; nucleus; protein binding; regulation of cell cycle
12505 Cd44 CD44 antigen 1 1.58595144 5.354951187 5.503931613 cell adhesion; defense response; external side of plasma membrane; hyaluronic acid binding; integral to membrane; membrane; receptor activity; ureteric bud branching
12575 Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 1 0.746817113 14.70759709 15.98057338 cell cycle; cell cycle arrest; cyclin binding; cyclin-dependent protein kinase holoenzyme complex; cyclin-dependent protein kinase inhibitor activity; kinase activity; negative regulation of CDK activity; nucleus; positive regulation of B-cell proliferation; protein binding; protein kinase inhibitor activity; regulation of cell cycle
12578 Cdkn2a cyclin-dependent kinase inhibitor 2A 1 1.119913704 2.508850811 2.536171169 DNA binding; aging; cell cycle; cell cycle arrest; cyclin-dependent protein kinase inhibitor activity; cytoplasm; epidermal differentiation; kinase activity; negative regulation of CDK activity; negative regulation of cell cycle; nucleolus; nucleoplasm; nucleus; protein binding; regulation of CDK activity; regulation of transcription, DNA-dependent; transcription factor activity
12778 Cmkor1 chemokine orphan receptor 1 1 0.701209428 13.35441787 14.64538579 G-protein coupled receptor activity; G-protein coupled receptor activity, unknown ligand; G-protein coupled receptor protein signaling pathway; chemokine receptor activity; chemotaxis; defense response; integral to membrane; purinergic nucleotide receptor activity, G-protein coupled; receptor activity; rhodopsin-like receptor activity
12904 Crabp2 cellular retinoic acid binding protein II 1 2.477143323 14.63799921 15.45925098 binding; lipid binding; transport; transporter activity
13051 Cx3cr1 chemokine (C-X3-C) receptor 1 1 0.160852549 5.377584751 5.776182898 C-C chemokine receptor activity; G-protein coupled receptor activity; G-protein coupled receptor protein signaling pathway; chemokine receptor activity; integral to membrane; receptor activity; rhodopsin-like receptor activity
13167 Dbi diazepam binding inhibitor 1 1.082932918 2.130016784 1.744663867 acyl-CoA binding; lipid binding; transport
13655 Egr3 early growth response 3 1 33.70553082 91.34476562 56.37781131 DNA binding; nucleus; regulation of transcription, DNA-dependent
13684 Eif4e eukaryotic translation initiation factor 4E 1 1.776196349 3.209729781 3.001167711 RNA binding; cytoplasm; protein biosynthesis; translational initiation
13803 Enc1 ectodermal-neural cortex 1 1 0.58938743 4.304589464 3.225312404 actin binding; cysteine-type endopeptidase activity; cytoskeleton; development; protein binding; proteolysis and peptidolysis
13805 Eng endoglin 1 0.683162746 19.29504498 23.4040682 angiogenesis; binding; cell adhesion; extracellular space; heart development; integral to membrane; regulation of transforming growth factor beta receptor signaling pathway
13821 Epb4.1l1 erythrocyte protein band 4.1-like 1 1 1.50159194 9.254976154 9.718186386 actin binding; cytoskeleton; protein binding; structural molecule activity
13874 Ereg epiregulin 1 1.467757398 48.11968508 38.98808966 angiogenesis; cell proliferation; extracellular space; growth factor activity; integral to membrane; regulation of cell cycle
14114 Fbln1 fibulin 1 1 0.081636097 6.565179039 8.191397517 calcium ion binding; extracellular; extracellular matrix; extracellular space
14155 Fem1b feminization 1 homolog b (C. elegans) 1 2.048860789 3.480014081 3.415411854 DNA binding; receptor activity; regulation of transcription, DNA-dependent; transcription factor activity
14205 Figf c-fos induced growth factor 1 2.221247527 2.517766627 3.57083688 angiogenesis; cell growth and/or maintenance; cell proliferation; extracellular; growth factor activity; membrane; protein binding; regulation of cell cycle; vascular endothelial growth factor receptor binding
14234 Foxc2 forkhead box C2 1 1.245760959 9.765634937 5.859506557 DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription factor activity; transcription factor complex
14283 Fosl1 fos-like antigen 1 1 1.248214768 3.616591622 4.139395393 DNA binding; nucleus; regulation of transcription, DNA-dependent
14319 Fth ferritin heavy chain 1 1.419527922 4.055440875 4.383640626 binding; ferric iron binding; iron ion homeostasis; iron ion transport
14468 Gbp1 guanylate nucleotide binding protein 1 1 3.440016906 31.83849003 57.32961543 GTP binding; GTPase activity; immune response
14469 Gbp2 guanylate nucleotide binding protein 2 1 1.252297763 39.80889804 72.66182493 GTP binding; GTPase activity; cellular_component unknown; immune response
14563 Gdf5 growth differentiation factor 5 1 0.266928183 4.951752661 5.515937188 cytokine activity; extracellular space; growth; growth factor activity; protein binding
15227 Foxf1a forkhead box F1a 1 0.724489823 6.669242764 7.474345435 DNA binding; lung development; nucleus; organogenesis; regulation of transcription, DNA-dependent; transcription factor activity; transcription factor complex; vasculogenesis
15258 Hipk2 homeodomain interacting protein kinase 2 1 2.01538064 7.53750855 7.977889903 ATP binding; PML body; cytoplasm; kinase activity; negative regulation of transcription from Pol II promoter; nucleus; protein amino acid phosphorylation; protein kinase activity; protein serine/threonine kinase activity; transcription corepressor activity; transferase activity
15361 Hmga1 high mobility group AT-hook 1 1 0.963609632 2.046686563 3.191937187 DNA binding; DNA packaging; chromatin; chromosome; chromosome organization and biogenesis (sensu Eukarya); nucleus; regulation of transcription, DNA-dependent
15364 Hmga2 high mobility group AT-hook 2 1 0.961298336 6.158861911 4.676201383 DNA binding; DNA packaging; chromatin; chromosome; chromosome organization and biogenesis (sensu Eukarya); nuclear chromosome; nucleus; regulation of transcription, DNA-dependent
15439 Hp haptoglobin 1 0.777647344 61.00102817 64.49218562 acute-phase response; chymotrypsin activity; extracellular space; hemoglobin binding; proteolysis and peptidolysis; trypsin activity
15461 Hras1 Harvey rat sarcoma virus oncogene 1 1 1.085724727 2.179557101 1.620337512 GTP binding; RAS protein signal transduction; RAS small monomeric GTPase activity; cell aging; cell growth and/or maintenance; regulation of cell cycle; small GTPase mediated signal transduction; small monomeric GTPase activity
16012 Igfbp6 insulin-like growth factor binding protein 6 1 1.535876352 1.824256969 2.111604802 extracellular; extracellular space; growth factor binding; insulin-like growth factor binding; regulation of cell growth
16156 Il11 interleukin 11 1 0.612588534 34.11300618 19.13895686 cytokine activity; extracellular space; growth factor activity
16193 Il6 interleukin 6 1 0.223733686 3.11025996 1.843848001 acute-phase response; cytokine activity; extracellular; extracellular space; growth factor activity; immune response; interleukin-6 receptor binding; negative regulation of chemokine biosynthesis; programmed cell death, neutrophils
16211 Impnb karyopherin (importin) beta 1 1 0.757366487 1.721162269 1.09608997 cytoplasm; intracellular protein transport; nuclear pore; nucleus; protein binding; protein transport; protein transporter activity; protein-nucleus import, docking; ribosomal protein-nucleus import; transport
16402 Itga5 integrin alpha 5 (fibronectin receptor alpha) 1 0.722865968 8.200610092 3.420389271 cell adhesion; cell-matrix adhesion; cell-substrate junction assembly; extracellular space; integral to membrane; integrin complex; integrin-mediated signaling pathway; memory; protein binding; receptor activity; synaptosome
16432 Itm2b integral membrane protein 2B 1 0.954956396 2.38096231 2.596865916 ATP binding; biological_process unknown; integral to membrane; membrane fraction
16776 Lama5 laminin, alpha 5 1 1.446827834 49.30690821 39.1181441 basal lamina; basement membrane; branching morphogenesis; cell adhesion; extracellular matrix; extracellular matrix structural constituent; extracellular space; integrin binding; lung development; metabolism; muscle development; organogenesis; oxidoreductase activity; protein binding; receptor activity; structural molecule activity; translation initiation factor activity; translational initiation
16784 Lamp2 lysosomal membrane glycoprotein 2 1 2.829903403 2.907066815 3.852042508 ATP binding; integral to membrane; lysosome; membrane; tRNA aminoacylation for protein translation; tRNA ligase activity
16790 Anpep alanyl (membrane) aminopeptidase 1 2.643642144 12.82612392 14.4587602 aminopeptidase activity; angiogenesis; hydrolase activity; integral to membrane; membrane alanyl aminopeptidase activity; metallopeptidase activity; proteolysis and peptidolysis; zinc ion binding
16859 Lgals9 lectin, galactose binding, soluble 9 1 1.238441791 4.212454541 6.201552765 heterophilic cell adhesion; sugar binding
16878 Lif leukemia inhibitory factor 1 0.096674558 5.657821075 3.727773808 cytokine activity; extracellular; extracellular space; growth factor activity; immune response; leukemia inhibitory factor receptor binding
16948 Lox lysyl oxidase 1 1.125539825 1.869037207 0.914635417 copper ion binding; extracellular space; oxidoreductase activity; protein-lysine 6-oxidase activity
17164 Mapkapk2 MAP kinase-activated protein kinase 2 1 1.185561597 2.22697887 2.198636767 ATP binding; kinase activity; mRNA stabilization; protein amino acid phosphorylation; protein kinase activity; protein serine/threonine kinase activity; protein-tyrosine kinase activity; transferase activity
17246 Mdm2 transformed mouse 3T3 cell double minute 2 1 0.737083884 7.465372344 6.520307046 cell growth and/or maintenance; ligase activity; nucleus; protein binding; protein catabolism; protein ubiquitination; traversing start control point of mitotic cell cycle; ubiquitin-protein ligase activity
17250 Abcc1a ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1 0.633792462 3.56420438 2.280238276 ATP binding; ATP-binding cassette (ABC) transporter activity; integral to membrane; integral to plasma membrane; membrane; membrane fraction; nucleotide binding; transport; transporter activity
17258 Mef2a myocyte enhancer factor 2A 1 5.579402938 7.340644232 3.556952216 DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription factor activity
17329 Scyb9 chemokine (C-X-C motif) ligand 9 1 0.060281313 0.43943586 2.383181909 chemokine activity; cytokine activity; extracellular; extracellular space; immune response; inflammatory response
17748 Mt1 metallothionein 1 1 3.242085877 10.03855696 11.26830095 copper ion binding; cytosol; lysosome; metal ion binding; metal ion homeostasis; nitric oxide mediated signal transduction; zinc ion binding; zinc ion homeostasis
17869 Myc myelocytomatosis oncogene 1 0.711678259 1.734120409 1.591893917 DNA binding; cell growth and/or maintenance; nucleus; protein binding; regulation of apoptosis; regulation of cell cycle; regulation of cell proliferation; regulation of transcription, DNA-dependent; transcription factor activity
18049 Ngfb nerve growth factor, beta 1 0.948041461 3.027857864 2.974966905 extracellular space; growth factor activity; perception of pain; receptor signaling protein activity
18129 Notch2 Notch gene homolog 2 (Drosophila) 1 0.640896743 5.291534914 3.689132697 DNA binding; calcium ion binding; cell differentiation; determination of left/right symmetry; development; extracellular space; integral to membrane; membrane; morphogenesis of an epithelial sheet; receptor activity; regulation of transcription, DNA-dependent; structural molecule activity; transcription factor activity
18294 Ogg1 8-oxoguanine DNA-glycosylase 1 1 3.66906037 5.807530528 4.793766114 DNA N-glycosylase activity; DNA binding; DNA repair; base-excision repair; carbohydrate metabolism; catalytic activity; endonuclease activity; hydrolase activity; hydrolase activity, acting on glycosyl bonds; lyase activity; mitochondrion; nuclease activity; nucleus; oxidized base lesion DNA N-glycosylase activity; purine-specific oxidized base lesion DNA N-glycosylase activity
18590 Pdgfa platelet derived growth factor, alpha 1 1.377744148 7.620035784 6.257211657 cell growth and/or maintenance; cell proliferation; extracellular space; growth factor activity; membrane; regulation of cell cycle; regulation of peptidyl-tyrosine phosphorylation
18654 Pgf placental growth factor 1 1.414551715 38.84660812 21.1242072 angiogenesis; cell growth and/or maintenance; cell proliferation; extracellular space; growth factor activity; membrane; regulation of cell cycle; ureteric bud branching
18787 Serpine1 serine (or cysteine) proteinase inhibitor, clade E, member 1 1 0.500005447 3.097915193 1.68189204 extracellular space; plasminogen activator activity; protein binding; regulation of angiogenesis; serine-type endopeptidase inhibitor activity
19039 Ppicap lectin, galactoside-binding, soluble, 3 binding protein 1 2.353186444 59.49359218 147.6282484 extracellular space; membrane; protein binding; scavenger receptor activity
19713 Ret ret proto-oncogene 1 0.942724433 5.034905527 4.20497281 ATP binding; calcium ion binding; cell adhesion; cell growth and/or maintenance; extracellular space; homophilic cell adhesion; integral to membrane; kinase activity; membrane; morphogenesis; protein amino acid phosphorylation; protein kinase activity; protein serine/threonine kinase activity; protein-tyrosine kinase activity; regulation of cell cycle; transferase activity; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase ligand binding; ureteric bud development
20249 Scd1 stearoyl-Coenzyme A desaturase 1 1 2.048472242 3.37169001 4.229118187 endoplasmic reticulum; fatty acid biosynthesis; integral to membrane; iron ion binding; membrane; oxidoreductase activity; stearoyl-CoA 9-desaturase activity
20296 Scya2 chemokine (C-C motif) ligand 2 1 1.047647624 38.00052591 63.0625648 G-protein-coupled receptor binding; chemokine activity; chemotaxis; cytokine activity; extracellular; extracellular space; immune response; inflammatory response; protein binding; signal transduction
20304 Scya5 chemokine (C-C motif) ligand 5 1 0.729618134 1.80204807 3.115153322 chemokine activity; chemotaxis; cytokine activity; extracellular; extracellular space; immune response; inflammatory response; signal transduction
20306 Scya7 chemokine (C-C motif) ligand 7 1 1.204496213 394.1284686 492.2640394 chemokine activity; chemotaxis; cytokine activity; extracellular; extracellular space; heparin binding; immune response; inflammatory response; membrane; receptor activity; signal transduction; transport; transporter activity
20311 Scyb5 chemokine (C-X-C motif) ligand 5 1 0.524251894 5.995560362 10.74096583 chemokine activity; cytokine activity; extracellular; extracellular space; immune response; signal transduction
20720 Serpine2 serine (or cysteine) proteinase inhibitor, clade E, member 2 1 2.227131204 7.802128008 7.80198153 extracellular space; heparin binding; serine-type endopeptidase inhibitor activity
20750 Spp1 secreted phosphoprotein 1 1 1.80870012 52.04684155 43.84871983 cell adhesion; cytokine activity; extracellular space; ossification
20846 Stat1 signal transducer and activator of transcription 1 1 0.745442508 4.963845178 9.402211774 DNA binding; cytoplasm; intracellular signaling cascade; nucleus; regulation of transcription, DNA-dependent; signal transducer activity; signal transduction; transcription factor activity
20848 Stat3 signal transducer and activator of transcription 3 1 0.998297478 4.062943918 4.480869108 DNA binding; JAK-STAT cascade; acute-phase response; cytoplasm; intracellular signaling cascade; nucleus; plasma membrane; protein binding; regulation of transcription from Pol II promoter; regulation of transcription, DNA-dependent; signal transducer activity; signal transduction; transcription factor activity; transcription from Pol II promoter; transcriptional activator activity
21336 Tacr1 tachykinin receptor 1 1 0.302064113 3.110251413 2.583374406 G-protein coupled receptor activity; G-protein coupled receptor protein signaling pathway; integral to membrane; neuropeptide Y receptor activity; plasma membrane; purinergic nucleotide receptor activity, G-protein coupled; response to pain; rhodopsin-like receptor activity; tachykinin receptor activity
21383 Tbx14 T-box 14 1 1.673280557 15.29493608 21.40769656 DNA binding; nucleus; regulation of transcription, DNA-dependent
21414 Tcf7 transcription factor 7, T-cell specific 1 2.054571102 4.615264912 4.096206442 DNA binding; Wnt receptor signaling pathway; nucleus; regulation of apoptosis; regulation of cell proliferation; regulation of transcription, DNA-dependent; transcription factor activity; transcription factor complex
21803 Tgfb1 transforming growth factor, beta 1 1 1.298163297 5.316192451 5.695507298 cell growth; cell proliferation; defense response; extracellular matrix; extracellular space; growth; growth factor activity; inflammatory response; lymph gland development; myogenesis; necrosis; negative regulation of cell proliferation; organogenesis; protein amino acid phosphorylation; protein binding; regulation of cell cycle; regulation of cell proliferation; regulation of myogenesis; regulation of protein-nucleus import; skeletal development; transforming growth factor beta receptor binding; transforming growth factor beta receptor signaling pathway
21807 Tgfb1i4 transforming growth factor beta 1 induced transcript 4 1 3.66410404 18.77398103 17.12282751 nucleus; regulation of transcription, DNA-dependent; transcription factor activity
21815 Tgif TG interacting factor 1 1.550698465 3.661690297 3.404669868 DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription factor activity; transcription factor complex
21817 Tgm2 transglutaminase 2, C polypeptide 1 0.533965132 3.687422237 4.581230751 acyltransferase activity; calcium ion binding; cysteine-type endopeptidase activity; peptide cross-linking; protein-glutamine gamma-glutamyltransferase activity; proteolysis and peptidolysis; transferase activity
21824 Thbd thrombomodulin 1 1.674687999 8.856858038 7.4119227 blood coagulation; calcium ion binding; embryonic development; extracellular space; integral to membrane; membrane; negative regulation of coagulation; plasma membrane; pregnancy; receptor activity; sugar binding; transmembrane receptor activity
21825 Thbs1 thrombospondin 1 1 1.234861957 10.3972253 8.528422669 calcium ion binding; cell adhesion; extracellular space; heparin binding; negative regulation of angiogenesis; structural molecule activity
22057 Tob1 transducer of ErbB-2.1 1 1.103952201 2.266963245 3.843780599 SMAD binding; SMAD protein nuclear translocation; cytoplasm; negative regulation of BMP signaling pathway; negative regulation of osteoblast differentiation; protein binding; transcription corepressor activity
22337 Vdr vitamin D receptor 1 1.910321425 3.542483731 3.133222536 DNA binding; calcium ion homeostasis; calcium ion transport; development; intestinal absorption; ligand-dependent nuclear receptor activity; nucleus; organogenesis; receptor activity; regulation of transcription, DNA-dependent; skeletal development; steroid hormone receptor activity; transcription; transcription factor activity
22339 Vegf vascular endothelial growth factor A 1 1.540619101 19.92975239 12.48316707 angiogenesis; cell growth and/or maintenance; cell proliferation; extracellular space; growth factor activity; heparin binding; membrane; mesoderm development; regulation of cell cycle
22388 Wdr1 WD repeat domain 1 1 0.727204376 1.574751365 1.219906655 actin binding; actin cytoskeleton; cytoskeleton; perception of sound
22671 Zfp179 zinc finger protein 179 1 0.897391713 16.22767089 5.028349463 integral to membrane; nucleic acid binding
26462 Txnrd2 thioredoxin reductase 2 1 2.088290376 5.292627508 4.696959106 cytoplasm; disulfide oxidoreductase activity; electron carrier activity; electron transport; metal ion binding; mitochondrion; oxidoreductase activity; oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor
26564 Ror2 receptor tyrosine kinase-like orphan receptor 2 1 0.300078601 7.93329941 3.017161622 ATP binding; development; extracellular space; integral to membrane; integral to plasma membrane; membrane; protein amino acid phosphorylation; protein kinase activity; protein serine/threonine kinase activity; protein-tyrosine kinase activity; receptor activity; skeletal development; transferase activity; transmembrane receptor activity; transmembrane receptor protein tyrosine kinase activity
29810 Bag3 Bcl2-associated athanogene 3 1 1.229839339 2.648681237 2.753128064 anti-apoptosis; apoptosis; chaperone activity; cytosol; protein binding; regulation of apoptosis
50493 Txnrd1 thioredoxin reductase 1 1 1.133767879 2.316315412 2.144906601 cytoplasm; cytosol; disulfide oxidoreductase activity; electron transport; metal ion binding; oxidoreductase activity; oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor; thioredoxin pathway; thioredoxin-disulfide reductase activity
50773 Dnt-pending 5',3'-nucleotidase, cytosolic 1 0.681393457 1.618146386 1.590337036 5'-nucleotidase activity; cellular_component unknown; deoxyribonucleotide catabolism; hydrolase activity; magnesium ion binding; nucleotide binding; nucleotide metabolism
53621 Cnot4 CCR4-NOT transcription complex, subunit 4 1 1.753952769 2.63222073 2.839261466 biological_process unknown; cellular_component unknown; nucleic acid binding
53892 Ppm1d protein phosphatase 1D magnesium-dependent, delta isoform 1 2.552926709 2.473834527 4.244793254 G2/M transition of mitotic cell cycle; catalytic activity; hydrolase activity; magnesium ion binding; magnesium-dependent protein serine/threonine phosphatase activity; manganese ion binding; protein amino acid dephosphorylation; protein serine/threonine phosphatase activity; protein serine/threonine phosphatase complex; response to pathogenic bacteria
54123 Irf7 interferon regulatory factor 7 1 0.572577412 9.710096984 32.75330604 DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription factor activity
56431 Dsn-pending destrin 1 0.767318721 4.62458325 4.684916354 actin binding; intracellular
56458 Foxo1 forkhead box O1 1 1.733013358 11.5604024 10.81870116 DNA binding; cytoplasm; insulin receptor signaling pathway; nucleus; regulation of cell proliferation; regulation of transcription, DNA-dependent; transcription factor activity
56506 Kip2-pending RIKEN cDNA 2810434I23 gene 1 2.314067683 26.33555668 21.51489492 calcium ion binding; kinase activity

Record Count = 96