metabolism
| GENENAME | LOCUSLINK | FOLD CHANGE | LOCUSLINK CLASSIFICATIONS |
|---|---|---|---|
| activin A receptor, type 1 | 11477 | 7.23894 | ATP binding; integral to membrane; kinase activity; membrane; protein amino acid phosphorylation; protein kinase activity; protein serine/threonine kinase activity; receptor activity; receptor signaling protein serine/threonine kinase activity; transferase activity; transforming growth factor beta receptor activity; transmembrane receptor protein serine/threonine kinase activity; transmembrane receptor protein serine/threonine kinase signaling pathway |
| activity-dependent neuroprotective protein | 11538 | 2.53189 | DNA binding; neuropeptide hormone activity; neuropeptide signaling pathway; nucleus; regulation of transcription, DNA-dependent; transcription factor activity |
| aryl-hydrocarbon receptor-interacting protein | 11632 | 1.65183 | protein folding; transcription cofactor activity; xenobiotic metabolism |
| thymoma viral proto-oncogene 2 | 11652 | 1.58658 | ATP binding; cell growth and/or maintenance; intracellular; protein amino acid phosphorylation; protein kinase activity; protein serine/threonine kinase activity; regulation of cell cycle; transferase activity |
| aldehyde dehydrogenase family 3, subfamily A2 | 11671 | 1.65332 | aldehyde dehydrogenase (NAD) activity; endoplasmic reticulum; integral to membrane; metabolism; microsome; oxidoreductase activity |
| aryl hydrocarbon receptor nuclear translocator | 11863 | 2.77673 | DNA binding; cytoplasm; nucleus; protein binding; receptor activity; regulation of transcription; regulation of transcription, DNA-dependent; response to toxin; signal transducer activity; signal transduction; transcription factor activity; transcription factor complex; transcriptional activator activity |
| activating transcription factor 1 | 11908 | 1.68331 | DNA binding; cysteine protease inhibitor activity; nucleus; protein binding; regulation of transcription, DNA-dependent; transcription factor activity; transcription factor complex |
| ATPase, H+ transporting, V0 subunit C | 11984 | 1.63323 | ATP biosynthesis; hydrogen ion transporter activity; hydrogen transport; hydrogen-exporting ATPase activity, phosphorylative mechanism; hydrogen-translocating V-type ATPase complex; hydrolase activity; integral to membrane; lysosomal lumen acidification; membrane; proton transport; proton-transporting ATP synthase complex (sensu Eukarya); vacuolar acidification |
| heterogeneous nuclear ribonucleoprotein D | 11991 | 1.59678 | DNA binding; RNA binding; chromosome, telomeric region; nucleic acid binding; nucleus; regulation of transcription, DNA-dependent; ribonucleoprotein complex; telomerase-dependent telomere maintenance |
| BarH-like homeobox 1 | 12022 | 4.5894 | DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription factor activity; transcription factor complex |
| caspase 3, apoptosis related cysteine protease | 12367 | 1.93779 | B-cell homeostasis; T-cell homeostasis; apoptosis; caspase activity; cyclin-dependent protein kinase inhibitor activity; cysteine-type peptidase activity; cytoplasm; hydrolase activity; induction of apoptosis; induction of apoptosis by oxidative stress; induction of apoptosis via death domain receptors; negative regulation of B-cell proliferation; negative regulation of CDK activity; negative regulation of activated T-cell proliferation; negative regulation of cell cycle; peptidase activity; proteolysis and peptidolysis |
| carbonyl reductase 1 | 12408 | 2.0603 | biological_process unknown; carbonyl reductase (NADPH) activity; cellular_component unknown; metabolism; oxidoreductase activity |
| cyclin K | 12454 | 1.78954 | cell cycle; cyclin-dependent protein kinase regulator activity; cytokinesis; mitosis; regulation of cell cycle; regulation of transcription, DNA-dependent |
| cyclin-dependent kinase 2 | 12566 | 2.26267 | ATP binding; cell cycle; cyclin-dependent protein kinase activity; cyclin-dependent protein kinase holoenzyme complex; cytokinesis; kinase activity; mitosis; nucleus; protein amino acid phosphorylation; protein binding; protein kinase activity; protein serine/threonine kinase activity; transcription factor complex; transferase activity |
| centromere autoantigen A | 12615 | 1.81624 | DNA binding; chromosome; chromosome organization and biogenesis (sensu Eukarya); chromosome, pericentric region; nucleosome; nucleosome assembly; nucleus |
| procollagen, type VI, alpha 1 | 12833 | 3.39965 | cell adhesion; collagen; extracellular matrix; extracellular matrix structural constituent; extracellular matrix structural constituent conferring tensile strength; extracellular space; proteolysis and peptidolysis; subtilase activity |
| carboxypeptidase D | 12874 | 2.31416 | carboxypeptidase A activity; carboxypeptidase activity; extracellular space; hydrolase activity; integral to membrane; proteolysis and peptidolysis |
| carnitine acetyltransferase | 12908 | 1.58129 | acyltransferase activity; carnitine O-acetyltransferase activity; fatty acid metabolism; mitochondrion; peroxisome; transferase activity; transport |
| cAMP responsive element binding protein-like 1 | 12915 | 3.14182 | DNA binding; endoplasmic reticulum; integral to membrane; nucleus; regulation of transcription, DNA-dependent; response to unfolded protein |
| phosphate cytidylyltransferase 1, choline, alpha isoform | 13026 | 2.56625 | biosynthesis; choline-phosphate cytidylyltransferase activity; membrane; nucleotidyltransferase activity; phosphatidylcholine biosynthesis; phospholipid biosynthesis; response to abiotic stimulus; transferase activity |
| D site albumin promoter binding protein | 13170 | 5.67315 | DNA binding; circadian rhythm; nucleus; regulation of transcription, DNA-dependent; rhythmic behavior |
| dihydrofolate reductase | 13361 | 1.49853 | dihydrofolate reductase activity; glycine biosynthesis; nucleotide biosynthesis; one-carbon compound metabolism; oxidoreductase activity |
| distal-less homeobox 2 | 13392 | 1.7825 | DNA binding; cell differentiation; development; nucleus; regulation of transcription, DNA-dependent; transcription factor activity; transcription factor complex |
| dentatorubral pallidoluysian atrophy | 13498 | 1.64992 | cytoplasm; nucleus; toxin metabolism; toxin receptor binding |
| eukaryotic translation initiation factor 4E binding protein 2 | 13688 | 2.32937 | cAMP-mediated signaling; cellular_component unknown; insulin receptor signaling pathway; protein binding; regulation of protein biosynthesis; regulation of translation; regulation of translational initiation |
| epoxide hydrolase 1, microsomal | 13849 | 2.46922 | aminopeptidase activity; catalytic activity; endoplasmic reticulum; epoxide hydrolase activity; extracellular space; hydrolase activity; integral to membrane; microsome; proteolysis and peptidolysis; response to toxin; xenobiotic metabolism |
| ets variant gene 6 (TEL oncogene) | 14011 | 3.69839 | DNA binding; cell differentiation; cell growth and/or maintenance; intracellular; nucleus; protein binding; regulation of cell cycle; regulation of transcription, DNA-dependent; transcription factor activity |
| Ewing sarcoma homolog | 14030 | 1.7204 | DNA binding; RNA binding; calmodulin binding; nucleic acid binding; nucleus; regulation of transcription, DNA-dependent |
| eyes absent 1 homolog (Drosophila) | 14048 | 2.7642 | development; hydrolase activity; metabolism; organogenesis; protein amino acid dephosphorylation; protein-tyrosine-phosphatase activity |
| ferrochelatase | 14151 | 1.72005 | detection of UV; ferrochelatase activity; heme biosynthesis; lyase activity; mitochondrial inner membrane; mitochondrion; porphyrin biosynthesis |
| feminization 1 homolog b (C. elegans) | 14155 | 1.9232 | DNA binding; receptor activity; regulation of transcription, DNA-dependent; transcription factor activity |
| FK506 binding protein 7 | 14231 | 2.31062 | calcium ion binding; endoplasmic reticulum; extracellular space; isomerase activity; peptidyl-prolyl cis-trans isomerase activity; protein folding |
| forkhead box M1 | 14235 | 1.58943 | DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription factor activity; transcription factor complex |
| glucose-6-phosphate dehydrogenase X-linked | 14381 | 1.81566 | glucose metabolism; glucose-6-phosphate 1-dehydrogenase activity; oxidoreductase activity |
| glucosidase, beta; acid | 14466 | 1.52828 | carbohydrate metabolism; extracellular space; glucosylceramidase activity; hydrolase activity; hydrolase activity, acting on glycosyl bonds; lysosome; lysosome organization and biogenesis; membrane; sphingolipid metabolism |
| amino-terminal enhancer of split | 14797 | 1.29986 | negative regulation of transcription; nucleus; protein binding; regulation of growth; skeletal development; transcription corepressor activity |
| goosecoid | 14836 | 1.66594 | DNA binding; development; nucleus; regulation of transcription, DNA-dependent; transcription factor activity |
| glutathione S-transferase, mu 5 | 14866 | 1.59463 | glutathione transferase activity; metabolism; transferase activity |
| glutathione S-transferase, mu 6 | 14867 | 1.46102 | glutathione transferase activity; metabolism; transferase activity |
| glutathione S-transferase, theta 1 | 14871 | 2.75857 | glutathione metabolism; glutathione transferase activity; nucleus; transferase activity |
| GTP binding protein 1 | 14904 | 1.62144 | GTP binding; protein biosynthesis; protein-synthesizing GTPase activity |
| histidine decarboxylase | 15186 | 1.42538 | amino acid metabolism; carboxy-lyase activity; catecholamine metabolism; histidine catabolism; histidine decarboxylase activity; lyase activity |
| homeodomain interacting protein kinase 2 | 15258 | 1.80352 | ATP binding; PML body; cytoplasm; kinase activity; negative regulation of transcription from Pol II promoter; nucleus; protein amino acid phosphorylation; protein kinase activity; protein serine/threonine kinase activity; transcription corepressor activity; transferase activity |
| high mobility group nucleosomal binding domain 2 | 15331 | 2.09436 | DNA binding; DNA packaging; chromatin; nucleus |
| heme oxygenase (decycling) 1 | 15368 | 1.93663 | heme oxidation; heme oxygenase (decyclizing) activity; integral to membrane; microsome; oxidoreductase activity |
| nuclear receptor subfamily 4, group A, member 1 | 15370 | 3.45432 | DNA binding; inhibition of caspase activation; ligand-dependent nuclear receptor activity; nucleus; receptor activity; regulation of transcription, DNA-dependent; steroid hormone receptor activity; transcription factor activity |
| heterogeneous nuclear ribonucleoprotein A/B | 15384 | 1.56487 | DNA binding; RNA binding; RNA processing; nucleic acid binding; nucleus; regulation of transcription, DNA-dependent; ribonucleoprotein complex; viral nucleocapsid |
| hypoxanthine guanine phosphoribosyl transferase | 15452 | 1.46526 | cytolysis; cytoplasm; hypoxanthine phosphoribosyltransferase activity; lymphocyte proliferation; magnesium ion binding; nucleoside metabolism; purine nucleotide biosynthesis; purine ribonucleoside salvage; transferase activity; transferase activity, transferring glycosyl groups |
| hypoxanthine guanine phosphoribosyl transferase | 15452 | 1.72097 | cytolysis; cytoplasm; hypoxanthine phosphoribosyltransferase activity; lymphocyte proliferation; magnesium ion binding; nucleoside metabolism; purine nucleotide biosynthesis; purine ribonucleoside salvage; transferase activity; transferase activity, transferring glycosyl groups |
| eukaryotic translation initiation factor 2 alpha kinase 1 | 15467 | 2.81474 | ATP binding; kinase activity; protein amino acid phosphorylation; protein kinase activity; protein serine/threonine kinase activity; protein-tyrosine kinase activity; regulation of translation; transferase activity |
| iduronate 2-sulfatase | 15931 | 2.13456 | extracellular space; hydrolase activity; iduronate-2-sulfatase activity; integral to membrane; lysosome; metabolism; sulfuric ester hydrolase activity |
| intergral membrane protein 1 | 16430 | 1.61945 | extracellular space; integral to membrane; membrane; oligosaccharyl transferase activity; protein amino acid glycosylation |
| Jun proto-oncogene related gene d1 | 16478 | 2.60892 | DNA binding; cell growth and/or maintenance; intracellular; nucleus; regulation of cell cycle; regulation of transcription, DNA-dependent; transcription factor activity |
| Kruppel-like factor 3 (basic) | 16599 | 2.24876 | DNA binding; nucleus; regulation of transcription, DNA-dependent |
| lysosomal membrane glycoprotein 2 | 16784 | 2.83013 | ATP binding; integral to membrane; lysosome; membrane; tRNA aminoacylation for protein translation; tRNA ligase activity |
| low density lipoprotein receptor | 16835 | 1.85977 | calcium ion binding; cholesterol homeostasis; cholesterol metabolism; coated pit; endocytosis; endosome; extracellular space; integral to membrane; lipid transport; lipid transporter activity; low-density lipoprotein receptor activity; membrane; protein binding; receptor activity |
| LIM domain only 4 | 16911 | 2.67317 | protein binding; transcription factor binding; transcription factor complex; transcription from Pol II promoter |
| mannosidase 1, beta | 17156 | 1.75374 | Golgi apparatus; Golgi membrane; N-linked glycosylation; calcium ion binding; carbohydrate metabolism; hydrolase activity; hydrolase activity, acting on glycosyl bonds; integral to membrane; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; membrane |
| MAP kinase-activated protein kinase 5 | 17165 | 2.03614 | ATP binding; kinase activity; protein amino acid phosphorylation; protein kinase activity; protein serine/threonine kinase activity; protein-tyrosine kinase activity; transferase activity |
| minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) | 17218 | 1.327 | ATP binding; DNA binding; DNA replication; DNA replication initiation; DNA-dependent ATPase activity; nucleus; regulation of transcription, DNA-dependent |
| solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 | 17254 | 1.61002 | alpha-amylase activity; carbohydrate metabolism; integral to membrane; protein binding |
| myocyte enhancer factor 2A | 17258 | 5.40759 | DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription factor activity |
| maternal embryonic leucine zipper kinase | 17279 | 1.94839 | ATP binding; cytoplasm; kinase activity; protein amino acid phosphorylation; protein kinase activity; protein serine/threonine kinase activity; protein-tyrosine kinase activity; transferase activity |
| midline 1 | 17318 | 2.2221 | intracellular; nucleus; regulation of transcription, DNA-dependent; zinc ion binding |
| Msx-interacting-zinc finger | 17344 | 1.48948 | DNA binding; RNA polymerase II transcription factor activity; nucleus; transcription, DNA-dependent |
| matrix metalloproteinase 11 | 17385 | 1.74497 | calcium ion binding; collagen catabolism; extracellular matrix; extracellular space; hydrolase activity; metalloendopeptidase activity; metallopeptidase activity; proteolysis and peptidolysis; zinc ion binding |
| malate dehydrogenase 2, NAD (mitochondrial) | 17448 | 2.15637 | L-malate dehydrogenase activity; malate dehydrogenase activity; malic enzyme activity; mitochondrion; oxidoreductase activity; tricarboxylic acid cycle |
| myeloid ecotropic viral integration site-related gene 1 | 17536 | 3.10515 | DNA binding; eye morphogenesis; nucleus; regulation of transcription, DNA-dependent; transcription factor activity |
| Max interacting protein 1 | 17859 | 3.72034 | DNA binding; nucleus; protein binding; regulation of transcription, DNA-dependent |
| Ngfi-A binding protein 1 | 17936 | 2.59734 | regulation of transcription, DNA-dependent |
| Ngfi-A binding protein 2 | 17937 | 2.48254 | regulation of transcription, DNA-dependent |
| N-acetyl galactosaminidase, alpha | 17939 | 2.66455 | alpha-galactosidase activity; carbohydrate metabolism; extracellular space; hydrolase activity; hydrolase activity, acting on glycosyl bonds; hydrolase activity, hydrolyzing O-glycosyl compounds |
| nuclear receptor coactivator 3 | 17979 | 2.18478 | nucleus; regulation of transcription, DNA-dependent; signal transducer activity; signal transduction; transferase activity |
| nuclear factor I/C | 18029 | 1.51328 | DNA binding; DNA replication; intracellular; nucleus; odontogenesis (sensu Vertebrata); regulation of transcription, DNA-dependent; transcription factor activity |
| nuclear factor I/X | 18032 | 3.71001 | DNA binding; DNA replication; intracellular; nucleus; regulation of transcription, DNA-dependent; transcription factor activity |
| nicotinamide nucleotide transhydrogenase | 18115 | 1.85975 | NAD(P) transhydrogenase activity; NAD(P)+ transhydrogenase (AB-specific) activity; NAD(P)+ transhydrogenase (B-specific) activity; electron transport; integral to membrane; mitochondrion; oxidoreductase activity; proton transport |
| nuclear respiratory factor 1 | 18181 | 1.7387 | DNA binding; carbohydrate metabolism; mitochondrion organization and biogenesis; nucleus; regulation of transcription, DNA-dependent; transcription factor activity; transcription factor complex |
| NAD(P) dependent steroid dehydrogenase-like | 18194 | 4.44579 | 3-beta-hydroxy-delta5-steroid dehydrogenase activity; cholesterol biosynthesis; cholesterol metabolism; integral to membrane; oxidoreductase activity; steroid biosynthesis |
| 8-oxoguanine DNA-glycosylase 1 | 18294 | 3.58126 | DNA N-glycosylase activity; DNA binding; DNA repair; base-excision repair; carbohydrate metabolism; catalytic activity; endonuclease activity; hydrolase activity; hydrolase activity, acting on glycosyl bonds; lyase activity; mitochondrion; nuclease activity; nucleus; oxidized base lesion DNA N-glycosylase activity; purine-specific oxidized base lesion DNA N-glycosylase activity |
| pre B-cell leukemia transcription factor 3 | 18516 | 2.80889 | DNA binding; anterior compartment specification; nucleus; posterior compartment specification; regulation of transcription, DNA-dependent; transcription factor activity; transcription factor complex |
| platelet derived growth factor receptor, beta polypeptide | 18596 | 1.38941 | ATP binding; extracellular space; integral to membrane; membrane; protein amino acid phosphorylation; protein kinase activity; protein serine/threonine kinase activity; protein-tyrosine kinase activity; receptor activity; regulation of peptidyl-tyrosine phosphorylation; signal transducer activity; signal transduction; transferase activity; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway |
| pyruvate dehydrogenase E1 alpha 1 | 18597 | 2.33876 | extracellular space; glycolysis; metabolism; mitochondrion; oxidoreductase activity; oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; pyruvate dehydrogenase (acetyl-transferring) activity; pyruvate dehydrogenase activity |
| period homolog 3 (Drosophila) | 18628 | 2.23063 | circadian rhythm; nucleus; regulation of transcription, DNA-dependent; rhythmic behavior; signal transducer activity; signal transduction |
| phosphatidylinositol glycan, class F | 18701 | 1.78065 | GPI anchor biosynthesis; endoplasmic reticulum; ethanolaminephosphotransferase activity; integral to membrane |
| protein kinase, cAMP dependent, catalytic, alpha | 18747 | 1.8799 | ATP binding; cAMP-dependent protein kinase activity; cytoplasm; mesoderm formation; nucleus; protein amino acid phosphorylation; protein kinase activity; protein serine/threonine kinase activity; protein-tyrosine kinase activity; transferase activity |
| protein kinase, cAMP dependent, catalytic, beta | 18749 | 3.08206 | ATP binding; protein amino acid phosphorylation; protein kinase activity; protein serine/threonine kinase activity; protein-tyrosine kinase activity; transferase activity |
| polymerase (DNA directed), alpha 2 | 18969 | 1.71072 | DNA replication; nucleus |
| polymerase (DNA directed), delta 2, regulatory subunit | 18972 | 2.1568 | DNA replication; DNA-directed DNA polymerase activity; nucleus; transferase activity |
| polymerase (DNA directed), epsilon 2 (p59 subunit) | 18974 | 1.59047 | DNA binding; DNA replication; DNA-directed DNA polymerase activity; nucleus; transferase activity |
| CCR4-NOT transcription complex, subunit 7 | 18983 | 2.45237 | CCR4-NOT complex; nucleus; positive regulation of transcription from Pol II promoter; protein binding; regulation of transcription, DNA-dependent; transcriptional activator activity |
| peroxisome proliferator activated receptor gamma | 19016 | 3.91878 | DNA binding; adipocyte differentiation; cytosol; inflammatory response; ligand-dependent nuclear receptor activity; nucleus; receptor activity; regulation of transcription, DNA-dependent; steroid hormone receptor activity; transcription factor activity |
| protective protein for beta-galactosidase | 19025 | 1.40582 | carboxypeptidase C activity; carboxypeptidase activity; catalytic activity; hydrolase activity; lysosome; protein binding; proteolysis and peptidolysis; serine carboxypeptidase activity |
| peptidylprolyl isomerase B | 19035 | 2.23029 | endoplasmic reticulum; extracellular space; isomerase activity; peptidyl-prolyl cis-trans isomerase activity; protein folding |
| protein kinase, AMP-activated, gamma 1 non-catalytic subunit | 19082 | 1.19904 | SNF1A/AMP-activated protein kinase activity; fatty acid biosynthesis; kinase activity; nucleus; response to stress |
| DnaJ (Hsp40) homolog, subfamily C, member 3 | 19107 | 1.59925 | cytoplasm; extracellular space; negative regulation of protein kinase activity; protein kinase inhibitor activity |
| prosaposin | 19156 | 1.53367 | extracellular space; lysosome; sphingolipid metabolism |
| protein tyrosine phosphatase, non-receptor type 13 | 19249 | 1.96708 | cytoskeleton; hydrolase activity; intracellular signaling cascade; phosphoprotein phosphatase activity; protein amino acid dephosphorylation; protein-tyrosine-phosphatase activity; receptor activity; structural molecule activity |
| protein tyrosine phosphatase, receptor type, A | 19262 | 1.89388 | hydrolase activity; integral to membrane; phosphoprotein phosphatase activity; plasma membrane; protein amino acid dephosphorylation; protein-tyrosine-phosphatase activity; receptor activity; transmembrane receptor protein tyrosine phosphatase signaling pathway |
| protein tyrosine phosphatase, receptor type, M | 19274 | 2.19021 | extracellular space; hydrolase activity; integral to membrane; membrane; phosphoprotein phosphatase activity; plasma membrane; protein amino acid dephosphorylation; protein-tyrosine-phosphatase activity; receptor activity; transmembrane receptor protein tyrosine phosphatase signaling pathway |
| retinoic acid receptor, gamma | 19411 | 1.64145 | DNA binding; ligand-dependent nuclear receptor activity; nucleus; receptor activity; regulation of transcription, DNA-dependent; retinoic acid receptor activity; steroid hormone receptor activity; transcription; transcription factor activity |
| retinoblastoma-like 1 (p107) | 19650 | 1.79321 | cell cycle; negative regulation of cell cycle; nucleus; protein binding; regulation of transcription, DNA-dependent; transcription factor complex |
| v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 19697 | 1.63241 | DNA binding; cell growth and/or maintenance; cytoplasm; defense response; nucleus; organogenesis; positive regulation of interleukin-12 biosynthesis; positive regulation of transcription, DNA-dependent; protein binding; regulation of cell cycle; regulation of transcription, DNA-dependent; transcription factor activity; transcriptional activator activity |
| D4, zinc and double PHD fingers family 2 | 19708 | 1.48267 | DNA binding; apoptosis; nucleus; regulation of transcription, DNA-dependent |
| ring finger protein 1 | 19763 | 1.8625 | chromatin modification; nuclear body; nucleus; protein binding; regulation of transcription, DNA-dependent; transcriptional repressor activity; zinc ion binding |
| expressed sequence C80913 | 19777 | 2.35966 | chaperone activity; prefoldin complex; protein folding |
| ribosomal protein L29 | 19944 | 1.3256 | cytosolic ribosome (sensu Eukarya); intracellular; protein biosynthesis; ribosome; ribosome biogenesis; structural constituent of ribosome |
| splicing factor 3a, subunit 2 | 20222 | 1.6352 | RNA binding; mRNA processing; nuclear mRNA splicing, via spliceosome; nucleic acid binding; nucleus; pre-mRNA splicing factor activity; spliceosome complex |
| spermidine/spermine N1-acetyl transferase 1 | 20229 | 2.85485 | N-acetyltransferase activity; acyltransferase activity; diamine N-acetyltransferase activity; spermine catabolism; transferase activity |
| stearoyl-Coenzyme A desaturase 1 | 20249 | 2.0253 | endoplasmic reticulum; fatty acid biosynthesis; integral to membrane; iron ion binding; membrane; oxidoreductase activity; stearoyl-CoA 9-desaturase activity |
| sialyltransferase 4C (beta-galactoside alpha-2,3-sialytransferase) | 20443 | 1.68111 | Golgi apparatus; beta-galactoside alpha-2,3-sialyltransferase activity; extracellular space; integral to membrane; membrane; protein amino acid glycosylation; sialyltransferase activity; transferase activity; transferase activity, transferring glycosyl groups |
| sine oculis-related homeobox 2 homolog (Drosophila) | 20472 | 1.4255 | DNA binding; development; nucleus; regulation of transcription, DNA-dependent; transcription factor activity; transcription factor complex |
| nuclear receptor co-repressor 2 | 20602 | 1.78452 | DNA binding; nucleus; receptor activity; regulation of transcription, DNA-dependent |
| serine palmitoyltransferase, long chain base subunit 2 | 20773 | 2.28696 | acyltransferase activity; biosynthesis; endoplasmic reticulum; integral to membrane; metabolism; serine C-palmitoyltransferase activity; transaminase activity; transferase activity |
| serine/threonine kinase 2 | 20874 | 1.72602 | ATP binding; DNA binding; kinase activity; nuclease activity; nucleotide-excision repair; protein amino acid phosphorylation; protein kinase activity; protein serine/threonine kinase activity; protein-tyrosine kinase activity; transferase activity |
| basic helix-loop-helix domain containing, class B2 | 20893 | 1.70733 | DNA binding; negative regulation of transcription, DNA-dependent; nucleus; protein binding; regulation of transcription, DNA-dependent; transcriptional repressor activity |
| steroid sulfatase | 20905 | 1.89047 | extracellular space; hydrolase activity; integral to membrane; metabolism; microsome; pregnancy; steroid metabolism; steryl-sulfatase activity; sulfuric ester hydrolase activity |
| suppressor of variegation 3-9 homolog 1 (Drosophila) | 20937 | 1.82373 | DNA packaging; chromatin; chromatin assembly/disassembly; chromatin binding; chromatin modification; methyltransferase activity; nuclear heterochromatin; nucleus; protein methyltransferase activity; transferase activity |
| transforming, acidic coiled-coil containing protein 3 | 21335 | 1.7165 | centrosome; cytoplasm; cytoplasmic sequestering of transcription factor; hemopoiesis; regulation of cell cycle; response to stress |
| TATA box binding protein | 21374 | 2.01117 | DNA binding; RNA polymerase I transcription factor complex; RNA polymerase II transcription factor activity; nucleus; protein binding; regulation of transcription, DNA-dependent; transcription; transcription factor TFIID complex; transcription factor activity; transcription factor complex; transcription initiation from Pol II promoter |
| transcription factor EB | 21425 | 1.82398 | DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription factor activity; transcription factor complex |
| upstream binding transcription factor, RNA polymerase I | 21429 | 1.7925 | DNA binding; nucleolus; nucleus; protein binding; regulation of transcription, DNA-dependent; transcription factor activity; transcription factor complex |
| thymine DNA glycosylase | 21665 | 1.93159 | DNA repair; carbohydrate metabolism; hydrolase activity; hydrolase activity, acting on glycosyl bonds; nucleus; protein targeting |
| thyrotroph embryonic factor | 21685 | 2.10475 | double-stranded DNA binding; nucleus; positive regulation of transcription from Pol II promoter; protein binding; transcriptional activator activity |
| testis specific protein kinase 1 | 21754 | 1.95203 | ATP binding; protein amino acid phosphorylation; protein kinase activity; protein serine/threonine kinase activity; protein-tyrosine kinase activity; transferase activity |
| transforming growth factor beta 1 induced transcript 4 | 21807 | 2.34809 | nucleus; regulation of transcription, DNA-dependent; transcription factor activity |
| thyroid hormone receptor alpha | 21833 | 3.34439 | cartilage condensation; cell growth and/or maintenance; nucleus; organogenesis; ossification; physiological process; receptor activity; regulation of cell cycle; regulation of heart rate; regulation of transcription, DNA-dependent; thyroid hormone receptor activity; transcription factor activity |
| TGFB inducible early growth response 1 | 21847 | 1.96799 | DNA binding; nucleus; regulation of transcription, DNA-dependent |
| transformation related protein 53 | 22059 | 1.52863 | DNA binding; DNA damage response, signal transduction by p53 class mediator; apoptosis; cytoplasm; cytosol; negative regulation of cell cycle; nucleus; protein binding; protein-nucleus import, translocation; regulation of cell proliferation; regulation of transcription, DNA-dependent; transcription; transcription factor activity |
| twist gene homolog 1 (Drosophila) | 22160 | 1.91125 | DNA binding; cell differentiation; development; limb morphogenesis; neurulation; nucleus; regulation of transcription, DNA-dependent |
| Unc-51 like kinase 1 (C. elegans) | 22241 | 1.78701 | ATP binding; kinase activity; protein amino acid phosphorylation; protein kinase activity; protein serine/threonine kinase activity; protein-tyrosine kinase activity; transferase activity |
| vitamin D receptor | 22337 | 1.76451 | DNA binding; calcium ion homeostasis; calcium ion transport; development; intestinal absorption; ligand-dependent nuclear receptor activity; nucleus; organogenesis; receptor activity; regulation of transcription, DNA-dependent; skeletal development; steroid hormone receptor activity; transcription; transcription factor activity |
| tryptophanyl-tRNA synthetase | 22375 | 1.58487 | ATP binding; ligase activity; protein biosynthesis; tRNA aminoacylation for protein translation; tRNA ligase activity; tryptophan-tRNA ligase activity; tryptophanyl-tRNA aminoacylation |
| zinc finger protein 162 | 22668 | 1.75027 | RNA binding; mRNA processing; nuclear mRNA splicing, via spliceosome; nucleic acid binding; nucleus; regulation of transcription, DNA-dependent; spliceosome complex |
| zinc finger protein, multitype 2 | 22762 | 2.28297 | cytoplasm; negative regulation of transcription from Pol II promoter; nucleic acid binding; nucleus; transcription corepressor activity |
| a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) | 23794 | 2.35815 | extracellular matrix; extracellular space; hydrolase activity; metalloendopeptidase activity; metallopeptidase activity; plasma membrane; protein amino acid prenylation; protein prenyltransferase activity; proteolysis and peptidolysis; zinc ion binding |
| ATP-binding cassette, sub-family E (OABP), member 1 | 24015 | 1.77854 | ATP-binding cassette (ABC) transporter activity; electron carrier activity; electron transport; membrane; nucleotide binding |
| zinc finger homeobox 1b | 24136 | 3.43035 | DNA binding; neural crest cell migration; nucleus; regulation of transcription, DNA-dependent; transcription factor activity |
| glucosamine-6-phosphate deaminase 1 | 26384 | 1.6544 | N-acetylglucosamine metabolism; acrosome reaction; carbohydrate metabolism; fructose 6-phosphate metabolism; fructose biosynthesis; glucosamine metabolism; glucosamine-6-phosphate deaminase activity; hydrolase activity |
| heat shock transcription factor 4 | 26386 | 2.67805 | DNA binding; heat shock protein activity; nucleus; regulation of transcription, DNA-dependent; transcription factor activity |
| mitogen activated protein kinase kinase 4 | 26398 | 2.80538 | ATP binding; MAPKKK cascade; kinase activity; protein amino acid phosphorylation; protein kinase activity; protein serine/threonine kinase activity; protein-tyrosine kinase activity; transferase activity |
| mitogen activated protein kinase 3 | 26417 | 1.36076 | ATP binding; MAP kinase activity; cell cycle; cytoplasm; kinase activity; nucleus; organogenesis; phosphorylation; phosphotyrosine binding; protein amino acid phosphorylation; protein binding; protein kinase activity; protein serine/threonine kinase activity; protein-tyrosine kinase activity; signal transduction; transferase activity |
| thioredoxin reductase 2 | 26462 | 2.17609 | cytoplasm; disulfide oxidoreductase activity; electron carrier activity; electron transport; metal ion binding; mitochondrion; oxidoreductase activity; oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor |
| pyruvate dehydrogenase kinase, isoenzyme 4 | 27273 | 2.14319 | ATP binding; acetyl-CoA biosynthesis from pyruvate; kinase activity; mitochondrion; protein threonine/tyrosine kinase activity; signal transduction; transferase activity; two-component sensor molecule activity |
| ERO1-like (S. cerevisiae) | 50527 | 2.86265 | integral to endoplasmic reticulum membrane; molecular_function unknown; protein folding |
| nucleosome assembly protein 1-like 1 | 53605 | 1.51213 | DNA binding; nucleosome assembly; nucleus |
| RING1 and YY1 binding protein | 56353 | 2.08641 | negative regulation of transcription from Pol II promoter; nucleoplasm; nucleus; protein binding; transcription corepressor activity |
| DnaJ (Hsp40) homolog, subfamily C, member 7 | 56354 | 1.49854 | chaperone activity; protein binding; protein folding |
| origin recognition complex, subunit 6-like (S. cerevisiae) | 56452 | 2.54755 | DNA binding; DNA replication; nucleus |
| pyrroline-5-carboxylate synthetase (glutamate gamma-semialdehyde synthetase) | 56454 | 1.61949 | amino acid biosynthesis; catalytic activity; glutamate 5-kinase activity; glutamate-5-semialdehyde dehydrogenase activity; inner membrane; kinase activity; mitochondrion; oxidoreductase activity; proline biosynthesis; transferase activity |
| receptor-interacting serine-threonine kinase 3 | 56532 | 3.11189 | ATP binding; NF-kappaB-inducing kinase activity; NIK-I-kappaB/NF-kappaB cascade; apoptosis; induction of apoptosis; intracellular; kinase activity; protein amino acid phosphorylation; protein kinase activity; protein serine/threonine kinase activity; protein-tyrosine kinase activity; transferase activity |
| ribosomal protein S6 kinase, polypeptide 4 | 56613 | 1.74279 | ATP binding; catalytic activity; nucleus; protein amino acid phosphorylation; protein kinase activity; protein serine/threonine kinase activity; protein-tyrosine kinase activity; transferase activity |
| ring finger protein 14 | 56736 | 1.9344 | ligase activity; nucleus; regulation of transcription, DNA-dependent |
| aldehyde dehydrogenase 9, subfamily A1 | 56752 | 1.97963 | aldehyde dehydrogenase (NAD) activity; aldehyde dehydrogenase activity; aldehyde metabolism; aminobutyraldehyde dehydrogenase activity; carnitine metabolism; cytosol; electron transporter activity; metabolism; oxidoreductase activity; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| ubiquitin specific protease 49 | 56771 | 1.75577 | biological_process unknown; cellular_component unknown; molecular_function unknown; nucleus; regulation of transcription, DNA-dependent |
| RIKEN cDNA E130014G12 gene | 56805 | 3.4174 | nucleus; protein binding; transcription |
| melanoma antigen, family D, 1 | 94275 | 2.94894 | cellular_component unknown; protein binding; regulation of transcription from Pol II promoter; transcription coactivator activity |