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Our work in Bone Group in Dep. of Periodontics in progress

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Microarray raw database sets (MLO-Y4, 2T3, mechanical stimulation)

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Wuchen Yang, Marie A. Harris, Dayong Guo, Lynda F. Bonewald, and Stephen E. Harris. Osteocyte and Osteoblast Cell Models have Unique Patterns of Gene Expression and Responses to Mechanical Loading. (in preparation) [Link]

Yang W, Lu Y, Kalajzic I, Guo D, Harris MA, Gluhak-Heinrich J, Kotha S, Bonewald LF, Feng JQ, Rowe DW, Turner CH, Robling AG, Harris SE. Dentin matrix protein 1 gene cis-regulation: Use In osteocytes to characterize local responses to mechanical loading in vitro and In vivo. J Biol Chem. 2005 Feb 22; [Epub ahead of print]; figures in RGB format

Yang W, Kalajzic I, Lu Y, Guo D, Harris MA, Gluhak-Heinrich J, Bonewald LF, Feng JQ, Rowe DW, Harris SE.In vitro and in vivo study on osteocyte-specific mechanical signaling pathways. J Musculoskelet Neuronal Interact. 2004 Dec;4(4):386-7. [PubMed]

Kalajzic I, Braut A, Guo D, Jiang X, Kronenberg MS, Mina M, Harris MA, Harris SE, Rowe DW. Dentin matrix protein 1 expression during osteoblastic differentiation, generation of an osteocyte GFP-transgene. Bone. 2004 Jul;35(1):74-82. [PubMed]

Zhao M, Qiao M, Harris SE, Oyajobi BO, Mundy GR, Chen D. Smurf1 inhibits osteoblast differentiation and bone formation in vitro and in vivo. Jounral of Biology Chemistry. 2004 Mar 26;279(13):12854-9. [PubMed]

Harris SE, Guo D, Harris MA, Krishnaswamy A, Lichtler A. Transcriptional regulation of BMP-2 activated genes in osteoblasts using gene expression microarray analysis: role of Dlx2 and Dlx5 transcription factors. Frontiers in Bioscience. 2003 Sep 1;8:s1249-65. [PubMed]

Gluhak-Heinrich J, Ye L, Bonewald LF, Feng JQ, MacDougall M, Harris SE, Pavlin D. Mechanical loading stimulates dentin matrix protein 1 (DMP1) expression in osteocytes in vivo. Journal of Bone and Mineral Research. 2003 May;18(5):807-17. [PubMed]

Feng JQ, Zhang J, Dallas SL, Lu Y, Chen S, Tan X, Owen M, Harris SE, MacDougall M. Dentin matrix protein 1, a target molecule for Cbfa1 in bone, is a unique bone marker gene. Journal of Bone and Mineral Research. 2002 Oct;17(10):1822-31. [PubMed]

Harris SE, Harris MA. Gene expression profiling in osteoblast biology: bioinformatic tools. Mol Biol Rep. 2001;28(3):139-56. [PubMed]